On December 7, it is the time of heavy snow. The ancients said heavy snow "Li out", is to say that although the weather is cold at this time, but "li" namely, Ma orchids can feel the germination of Yang and draw out new buds.

On this day, Chongqing Bio-Intelligent Manufacturing Research Institute established deep cooperation with Shenzhen Yizhi Medical Technology Co., LTD., which has rich experience in implant application and sales network, by virtue of its strong ability in biomedical materials and clinical implant product R&D and clinical certification. Shenzhen Yizhi Oral Biological Medical Co., Ltd. was jointly established by both sides to focus on key dental implant technologies. Develop new products of high quality dental implants.

At present, about 90% of the domestic market share of oral implants are imported products, among which the high-end products from Europe and the United States are represented by Nobel, ITI, Bego, Hao SAN /Hiossen, Anthogyr, and generally have more than 50 years of design, production and application history. The product price is high (some more than 10,000 yuan/piece). Korean brands such as Dentium, Odentium (osstem) also have a certain market share, the product price is lower relative to Europe and the United States. However, the market share of domestic brands is very low. Relative to foreign brands, relevant brand products are obviously insufficient in material selection and technology precipitation, and the price is lower.

The policy of large-scale collection of dental implants in 2022 will certainly have an impact on high-priced imported implant products, providing opportunities for domestic implant products to be quickly introduced to the market and to rapidly increase market share.

Shenzhen Easy Planting Medical Technology Co., Ltd. is invested and established by Shenzhen Helai Technology Co., LTD., which focuses on the collective digital dental implant industry chain. Its core business is the research and development, production and sales of dental implant accessories and tools. The products have covered more than 200 mainstream planting systems in the world, involving more than 2000 categories. By 2022, Yizhi Medical has obtained 16 patents and 15 medical device registration and production licenses. Shenzhen Helai Technology Company is dedicated to helping dentists solve complex challenges in restorative dentistry while improving the quality of life for oral patients around the world. Has formed the mouth from diagnosis - grow - healing - transfer - repair - printing - cutting the whole chain of one-stop service. Respectively in South China, East China, North China, Northwest, Southwest, Central China, northeast set up branches or offices. To provide customers with local and fast services. Domestic business covers 30 provinces and cities, thousands of denture processing plants and dental clinics. Overseas markets to the United States, Europe, Southeast Asia, the Middle East and other countries and regions.

Since its establishment, Chongqing Bio-Intelligent Manufacturing Research Institute has been taking implant surface modification as one of the main research directions, and has achieved fruitful results. Appropriate biological functional materials on the implant surface can not only effectively prevent the degradation of the implant and improve the biological safety, but also effectively promote the fusion and growth of bone tissue and implant, greatly extending the service life of the implant. Therefore, the layer of biological functional materials on the surface of the implant becomes a highly technical part of the implant design in addition to the optimization of the geometric shape design, which significantly affects the actual use experience of the implant.

The metal implant research team led by Dr. Liu Yingrui from the Research Institute has been focusing on the basic and clinical application research of surface functional modification of human metal implants for a long time, and was successfully selected into the 2022 Chongqing Bo Xin Program in September.

In terms of technical research, the research team has carried out systematic technical development and research in the surface modification of degradable magnesium alloy implants, personalized all-titanium joint and implant surface anti-abrasion, and bone promoting coating materials, especially focusing on the surface functional modification technology of oral implants, and striving to realize the development and application of domestic high-quality and low-cost implants as soon as possible. Efforts are made to promote the promotion of domestic high-end implants to benefit domestic oral patients with higher product quality and lower price.

In terms of hardware platform, the institute has built metal 3D printing, multifunctional composite technology coating deposition preparation platform, material comprehensive physical property evaluation platform, standardized material processing and clean production workshop of over thousand square meters (grade 10,000, grade 100), and will be reviewed by the State Food and Drug Administration in June 2023 titanium alloy base coating preparation master document record. In order to serve the entire industry of orthopedic joints, wear-resistant medical surgical tools and oral implants, which fully shows the strong research and development capability of the institute in surface functional modification and the development and design of various coating materials.

Shenzhen Yizhi Dental Biomedical Co., Ltd. plans to complete the research and development and registration of dental implants in the next two years, and is expected to achieve an annual sales of 100,000 implants within five years.

"One can only reach one's goal by one's own means."

The first seedling cultivated by the Chongqing Bio-Intelligent Manufacturing Research Institute will surely grow strong and bear fruit, providing quality domestic products for people's health and giving back to society.

(Chongqing Institute of Biological Intelligent Manufacturing Comprehensive Office)